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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Immunol. 2021 Jun 16;207(1):110–114. doi: 10.4049/jimmunol.2100046

FIGURE 4.

FIGURE 4.

PD-L1 interacts with CD80 in cis to boost AM phagocytosis. (A) CD80 expression on the AMs of wild type (WT) but not CD80 deficient (CD80KO) mice. (B) Co-localization of PD-L1 and CD80 on AMs. (C) Decreased phagocytic ability of CD80KO AMs (n = 16). (D) High phagocytic ability of AMs expressing high CD80 on the surface (n = 6). (E) PD-1 expression on AMs (n = 6). (F) Increased co-localization of PD-L1 and PD-1 on CD80KO AMs. (G) Enhanced phagocytic ability of AMs by PD-1 deletion (n = 6). Scale bar: 1 μm. Student’s t test was performed (two tailed, unpaired for C, F, G and paired for D, E) and data represent means ± SEM. **P < 0.01.