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. 2021 Nov 30;12(12):947–964. doi: 10.1007/s13238-021-00865-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of pESC-PGCLCs and PGCs at DNA methylation levels. (A) Correlation factors of genome-wide DNA methylation levels in E9.5 PGCs, E12.5 PGCs, ESC-PGCLCs and pESC-PGCLCs as well as ESCs and pESCs. (B) Heatmap showing genome-wide DNA methylation levels at different gene regions of E9.5 PGCs, E12.5 PGCs, ESC-PGCLCs and pESC-PGCLCs. (C) Genome-wide DNA methylation level in gene body regions including up- and down-stream 2 kb of gene body. (D) Methylation level of maternal and paternal imprinting genes in pESC-PGCLCs, ESC-PGCLCs, E9.5 PGCs and E12.5 PGCs. Methylation counts are provided in Table S1. (E) Box plot showing DNA methylation levels of maternal and paternal imprinting in pESC-PGCLCs, ESC-PGCLCs, E9.5 PGCs and E12.5 PGCs. (F) Box plot showing global DNA methylation levels of X chromosomes in pESC-PGCLCs, ESC-PGCLCs, E9.5 PGCs and E12.5 PGCs. Data shown as mean ± SEM. *P < 0.05, **P < 0.01; ***P < 0.001. RRBS analysis represents two biological replicates