Table 4.
Relationship between hyponatremia and 30 days in-hospital death in hospitalized patients with COVID-19.
| Relationship between hyponatremia and 30 days in-hospital death | ||||
|---|---|---|---|---|
| Hazard ratio (95% confidence interval) | ||||
| Variable | Unadjusted model | Adjusted model by age and comorbidities | Adjusted model by Charlson score and comorbidities | Sensitivity analysis |
| Hyponatremia | 3.05 (2.14-4.34) | 2.76 (1.88-4.06) | 2.51 (1.72–3.65) | 3.08 (1.35–6.99) |
| Age | – | 2.91 (1.96–4.33) | – | 2.45 (1.1–5.43) |
| Hypernatremia | – | 12.53 (3.54–44.35) | 6.69 (1.94–23.09) | – |
| Acute kidney injury (AKI) | – | 2.36 (1.44–3.88) | 3.13 (1.96–5.0) | 1.71 (0.67–4.36) |
| Morbid obesity | – | 4.82 (1.43–16.2) | 3.38 (1.02–11.22) | – |
| Congestive heart failure | – | 2.98 (1.72–5.17) | – | – |
| Chronic liver disease | – | 3.9 (1.41–10.82) | – | – |
| Cancer | – | 2.34 (1.43–3.84) | – | – |
| Non-dialysis-requiring chronic kidney disease | – | 3.39 (1.58–7.28) | – | 0.65 (0.18–2.36) |
| Receiving chronic dialysis | – | 4.07 (1.98–8.35) | – | – |
| HIV | – | 3.35 (1.01–11.15) | – | – |
| Asthma | – | 2.26 (1.1–4.62) | 1.81 (0.91–3.62) | – |
| Obesity | – | 0.66 (0.38–1.14) | 0.66 (0.39–1.12) | 0.35 (0.08–1.53) |
| Chronic neurological diseases | – | – | – | 2.38 (1.02–5.58) |
| Hypertension | – | 1.37 (0.93–2.01) | 1.4 (0.96–2.03) | 0.69 (0.3–1.58) |
| Charlson score | – | – | 1.31 (1.23–1.4) | – |
p-Values < 0.05 are highlighted in bold.