Figure 3.

Absolute quantification of major clinically-relevant hepatic DMEs (A) and transporters (B). Protein expression levels are presented as mean with standard deviation (SD). For human hepatic DMEs, all studies used HLM samples. For transporters, the DIA studies used HLM samples while the targeted proteomics studies used membrane protein preparations. Values determined by DIA methods are highlighted in red whereas values determined by targeted assays are in black and white. For transporters, the different sample preparation methods (i.e., HLM vs. membrane proteins) should be taken into consideration when comparing results obtained from DIA and targeted proteomics methods.