Table 1.
Distribution of HBR-ARC criteria.
|
All N= 1,080 |
HBR N= 354 |
LBR N= 726 |
p-value | |
|---|---|---|---|---|
| Major HBR criteria | ||||
| Long-term OAC, n (%) | 130 (12.0) | 130 (36.7) | 0 (0) | <0.01 |
| eGFR <30 ml/min, n (%) | 24 (2.2) | 24 (6.8) | 0 (0) | <0.01 |
| Hemoglobin < 11 g/dL, n (%) | 55 (5.1) | 55 (15.5) | 0 (0) | <0.01 |
| Recent or recurrent major bleeding, n (%) | 1 (0.1) | 1 (0.3) | 0 (0) | 0.33 |
| Platelet count <100 G/L, n (%) | 12 (1.1) | 12 (3.4) | 0 (0) | <0.01 |
| Chronic bleeding diathesis, n (%) | 0 (0) | 0 (0) | 0 (0) | na |
| Liver cirrhosis with portal hypertension, n (%) | 4 (0.4) | 4 (1.1) | 0 (0) | <0.01 |
| Active malignancy < 12 months, n (%) | 19 (1.8) | 19 (5.4) | 0 (0) | <0.01 |
| Previous spontaneous ICH (any time), previous traumatic ICH < 12 months, presence of bAVM, major ICH < 6 months, n (%) | 5 (0.5) | 5 (1.4) | 0 (0) | <0.01 |
| Non-deferrable major surgery on DAPT, n (%) | 6 (0.6) | 6 (1.7) | 0 (0) | <0.01 |
| Recent major surgery or major trauma <30 days before PCI, n (%) | 0 (0) | 0 (0) | 0 (0) | na |
| Minor HBR criteria | ||||
| Age ≥ 75 years, n (%) | 282 (26.1) | 211 (60.0) | 71 (9.8) | <0.01 |
| eGFR 30–59mL/min, n (%) | 213 (19.7) | 183 (51.7) | 30 (4.1) | <0.01 |
| Hemoglobin 11–12.9 g/dL for men and 11–11.9 g/dL for women, n (%) | 150 (13.9) | 108 (30.5) | 42 (5.8) | <0.01 |
| Spontaneous major bleeding not meeting the major criterion, n (%) | 0 (0) | 0 (0) | 0 (0) | na |
| Long-term use of oral NSAIDs or steroids, n (%) | 60 (5.6) | 41 (11.6) | 19 (2.6) | <0.01 |
| Any ischemic stroke > 6 months, n (%) | 45 (4.2) | 31 (8.8) | 14 (1.9) | <0.01 |
bAVM, brain arteriovenous malformation; DAPT, dual antiplatelet therapy; eGFR, eGFR, estimated glomerular filtration rate; HBR, high bleeding risk; LBR, low bleeding risk, ICH, intracerebral hemorrhage; NSAIDs, Non-steroidal anti-inflammatory drugs; OAC, oral anticoagulation. eGFR: the closest plasma creatinine value before the procedure was taken, excluding values that may be consistent with acute renal failure; Hemoglobin: same reasoning as for eGFR; Platelet count: same reasoning as for eGFR and Hb; Non-deferrable major surgery on DAPT: we considered that any patient who had surgery that was done under DAPT was assigned this major criterion.