Table 3.
Associations between overall survival and clinicopathological characteristics in patients in TCGA using Cox regression.
| Characteristics | Total (N) | HR (95% CI) | P -value | HR (95% CI) | P -value |
|---|---|---|---|---|---|
| Univariate analysis | univariate analysis | multivariate analysis | multivariate analysis | ||
| T stage (T3 and T4 vs. T1 and T2) | 362 | 1.719 (1.131–2.612) | 0.011 | 1.101 (0.590–2.054) | 0.763 |
| N stage (N1 and N2 and N3 vs. N0) | 352 | 1.925 (1.264–2.931) | 0.002 | 1.421 (0.672–3.006) | 0.357 |
| M stage (M1 vs. M0) | 352 | 2.254 (1.295–3.924) | 0.004 | 0.991 (0.382–2.572) | 0.985 |
| Pathologic stage (Stage III and Stage IV vs. Stage I and Stage II) | 347 | 1.947 (1.358–2.793) | <0.001 | 1.285 (0.676–2.440) | 0.444 |
| Histologic grade (G3 vs. G1 and G2) | 361 | 1.353 (0.957–1.914) | 0.087 | 1.349 (0.840–2.167) | 0.215 |
| Histological type (diffuse type vs. tubular type) | 132 | 1.077 (0.620–1.872) | 0.793 | ||
| Primary therapy outcome (CR vs. PD and SD and PR) | 313 | 0.237 (0.163-0.344) | <0.001 | 0.223 (0.142–0.350) | <0.001 |
| Residual tumor (R1 and R2 vs. R0) | 325 | 3.445 (2.160–5.494) | <0.001 | 1.307 (0.662–2.581) | 0.441 |
| Age (>65 vs. ≤ 65) | 367 | 1.620 (1.154–2.276) | 0.005 | 1.736 (1.118–2.698) | 0.014 |
| Race (Asian and Black or African American vs. White) | 320 | 0.801 (0.515–1.247) | 0.326 | ||
| Gender (male vs. female) | 370 | 1.267 (0.891–1.804) | 0.188 | ||
| Anatomic neoplasm subdivision (fundus/body vs. antrum/distal) | 267 | 0.965 (0.651–1.430) | 0.858 | ||
| Reflux history (yes vs. no) | 213 | 0.582 (0.291–1.162) | 0.125 | ||
| Antireflux treatment (yes vs. no) | 179 | 0.756 (0.422–1.353) | 0.346 | ||
| Barretts esophagus (yes vs. no) | 207 | 0.892 (0.326-2.441) | 0.824 | ||
| TP53 status (Mut vs. WT) | 367 | 0.865 (0.621–1.205) | 0.392 | ||
| PIK3CA status (Mut vs. WT) | 367 | 0.623 (0.370–1.048) | 0.075 | 0.675 (0.370–1.234) | 0.202 |
| MSC-AS1 (high vs. low) | 370 | 1.753 (1.254–2.451) | 0.001 | 1.681 (1.057–2.673) | 0.028 |