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. 2021 Dec 2;12:772941. doi: 10.3389/fimmu.2021.772941

Figure 1.

Figure 1

Development of dry skin symptoms and increased TSLP levels in AEW-treated mice. (A) Schematic illustration of the treatment protocol with AEW. (B) Images of the mouse skin, with or without AEW treatment. (C) A graph of the skin lesion scores of the control (n = 6) and AEW-treated mice (n = 6), as measured on different days. (D) Representative H&E-stained images of the skin tissues collected on day 5. (E) The thickness of the epidermis significantly increased on day 5 following AEW treatment (n = 6), compared to that of the control (n = 6). (F) The values of TEWL significantly increased on days 3 and 5 following AEW treatment (n = 9). (G) The spontaneous scratching bouts significantly increased in the AEW-treated mice (n = 5) on day 5, compared to those of the control (n = 5). (H) The transcriptional levels of Tslp significantly increased in the keratinocytes of AEW-treated mice. (I) The serum levels of TSLP significantly increased in the AEW-treated mice (n = 3) on day 5, compared to those of the control (n = 3). (J) The skin levels of TSLP increased on day 5 after treatment with AEW, compared to those of the control (n = 6). **p < 0.01, ***p < 0.001.