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. 2021 Dec 2;12:772941. doi: 10.3389/fimmu.2021.772941

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Copyright © 2021 Lee and Shim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The symptoms of dry skin and reduction in TSLP levels were less pronounced in TRPV4-deficient mice following AEW treatment. (A) The skin of Trpv4 ^-/- mice appeared less dry following AEW treatment. (B) On day 5 after treatment with AEW, the skin lesion scores gradually decreased in the following order: Trpv4^+/+ (n = 6) > Trpv4^+/- (n = 6) > Trpv4 ^-/- (n = 6). (C) Representative H&E-stained images of the skin tissues of Trpv4^+/+ and Trpv4 ^-/- mice following AEW treatment. (D) The epidermal thickness significantly decreased in both AEW-treated Trpv4^+/- mice (n = 6) and Trpv4 ^-/- mice (n = 6). (E) The values of TEWL significantly reduced in the AEW-treated Trpv4^+/- mice (n = 6) and Trpv4 ^-/- mice (n = 6). (F) The spontaneous scratching bouts were reduced in AEW-treated Trpv4^+/- mice (n = 6) and Trpv4 ^-/- mice (n = 6). (G) The serum levels of TSLP significantly decreased in the AEW-treated Trpv4^+/- mice (n = 6) and Trpv4 ^-/- mice (n = 6). (H) The levels of TSLP in the skin significantly reduced in the AEW-treated Trpv4 ^-/- mice (n = 6), compared to those of the control (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001.