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. 2021 Nov;10(11):4221–4234. doi: 10.21037/tlcr-21-570

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2021 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Clinical relevance of detected genetic alterations. (A,D) UICC stage significantly correlates with the application of targeted therapy, but not with the presence of a targetable alteration (Mann-Whitney test); (B,E) Age significantly negatively correlates with the application of targeted therapy, but not with the presence of a targetable alteration (Mann-Whitney test); (C,F) The number of pack-years significantly negatively correlates with the presence of a targetable alteration, but not with the application of targeted therapy (Mann-Whitney test); (G) Comparison of detected targetable alterations, applied targeted therapy (mutation and fusion specific), and detected emerging biomarkers between both subgroups (patients from 2019 and 2020).