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The clinical course. All three cases were histologically identified as transformed after EGFR-TKI treatment. HE, hematoxylin-eosin; DEL, deletion mutation in exon 19; EGFR, epidermal growth factor receptor; CBDCA, carboplatin; GEM, gemcitabine; PEM, pemetrexed; Bev, bevacizumab; PTX, paclitaxel; TBLB, transbronchial lung biopsy, DOC, docetaxel; Nivo, nivolumab.
