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. 2021 Nov;10(11):4161–4173. doi: 10.21037/tlcr-21-536

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2021 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Autopsy findings in case 1. (A) Immunohistochemical staining at the border of coexistent metastasis in the left upper lung lobe, indicated as arrow in (C). Adenocarcinoma in the upper region is in contact with the small-cell carcinoma in the lower region. (B) Immunohistochemical staining of isolated histological lesions indicated as arrowheads in (C). (C) Schema of tumor distribution at case 1 autopsy. HE, hematoxylin-eosin; CK, cytokeratin; EGFR, epidermal growth factor receptor; MET, mesenchymal-to-epithelial transition; ASCL1, Achaete-scute homolog 1; Rb, retinoblastoma.