Table 1. Additive and lost alterations common in three cases.

Added/Lost	Gene name	Chr	Position GRCh37	COSMIC ID	Reference	Variant	Variant type	Codon change	Amino acid change	SNP effect
Added	MTOR	Chr1	11166624	–	C	<DUP>	CNV	–	–	UTR 3 PRIME
	JAK1	Chr1	65300216	–	C	<DUP>	CNV	–	–	UTR 3 PRIME
	NOTCH2	Chr1	120457873	–	T	<DUP>	CNV	–	–	UTR 3 PRIME
	CSF1R	Chr5	149435535	–	G	T	SNP	–	–	INTRON
Lost	MAP2K2	Chr19	4090533	–	G	<DUP>	CNV	–	–	UTR 3 PRIME

Chr, chromosome; CNV, copy number variation; DUP, duplicate; SNP, single-nucleotide polymorphism; UTR, untranslated region.