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. 2021 Dec 2;8:754741. doi: 10.3389/fsurg.2021.754741

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Copyright © 2021 Mazzucchelli, Marzioni, Tossetta, Pepi and Montironi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Extension of bladder tumor transmurally invasion classified considering 2017 version of AJCC TNM classification as described in the text. The arrows indicate different depths in relation to the different histological tumor stages. (B) Bladder wall Black arrows indicate the vascular plexus (VP) and the muscularis mucosae (MM), these divide the lamina propria in two part and represent the landmark to subclassified T1 tumors. (C) The arrow indicates the urothelial carcinoma infiltrating the lamina propria. (D) Small groups of tumor cells into two lymphatic vessels.