Table 1: FFR and iFR use for Myocardial Ischaemia Assessment in TAVI.
| Study | No. of Patients (No. of Lesions) | FFR/iFR Values Pre-TAVI | FFR/iFR Values After TAVI | PCI Treatment After FFR | Follow-up |
|---|---|---|---|---|---|
| Stanojevic et al. 2016[23] | 72 (82 lesions) | FFR ≤0.80 (0.76 ± 0.03) FFR >0.80 (0.88 ± 0.04) |
– | 37 lesions (45.10%) | 9 ± 14 months after TAVI: 4 ACS, no TVR or TLR |
| Pesarini et al. 2016[21] | 54 (133 lesions) | FFR (LAD) ≤0.80 (0.72 ± 0.12) FFR (LAD) >0.80 (0.88 ± 0.12) |
FFR (LAD) ≤0.8 (0.69 ± 0.13) FFR (LAD) >0.8 (0.89 ± 0.13) |
19 lesions (14.20%) | At 30 days: no sustained angina or hypotension, MI or heart failure |
| Scarsini et al. 2018[22] | 62 (141 lesions) | FFR 0.88 ± 0.09 iFR <0.83 (0.69 ± 0.11) iFR 0.83–0.93 (0.88 ± 0.11) iFR >0.93 (0.95 ± 0.11) |
FFR 0.87 ± 0.08 iFR <0.83 (0.71 ± 0.13) iFR 0.83–0.93 (0.88 ± 0.10) iFR >0.93 (0.95 ± 0.10) |
19 lesions (13.40%) | At 30 days: no death or new coronary revascularisation |
| Ahmad et al. 2018[20] | 28 (30 lesions) | FFR 0.87 ± 0.08 iFR 0.88 ± 0.09 |
FFR 0.85 ±0.09 iFR 0.88 ±0.09 |
– | – |
| Lunardi et al. 2019[24] | 94 (142 lesions) | FFR 0.87 ± 0.12 | FFR 0.87 ±0.08 | 31 lesions (21.80%) | 24.2 ± 17 months after TAVI: 16 death; 3 cardiac deaths; 4 AMI; 1 elective PCI; 1 stroke; 7 MACCE |
AMI = acute MI; ACS = acute coronary syndrome; FFR = fractional flow reserve; iFR = instant wave-free ratio; LAD = left anterior descending; MACCE = major adverse coronary and cerebrovascular events; TAVI = transcatheter aortic valve implantation; TLR = target lesion revascularisation; TVR = target vessel revascularisation.