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. 2021 Dec 11;14:6813–6831. doi: 10.2147/JIR.S338242

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© 2021 Luan et al.

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Cell–cell interactions between microglia and OLGs in aged CNS. (A) Dot plot depicting the interactions between different subclusters in microglia and OLGs regarding GO term immune response (GO:0006955), using DEGs for each subcluster in aged brain. Node color and size represented the strength and the count of interaction pairs, respectively. (B) Volcano plot showing the cytokines acting on OLG C2 subset released by microglia C3 subset. DEGs compared with other microglia subclusters (|log2 fold change| > 0.5 and Bonferroni adjusted P-value < 0.05) were colored, red for upregulation and blue for downregulation. (C) Heatmap of the average expression of white matter associated microglia (WAM) signature genes (Geneset 1–4) for each microglia subcluster, along with the populations mentioned by Safaiyan et al. Values were normalized per gene. (D) Expression profiles of phagosome and lipid metabolism related genes and homeostatic genes in microglia were shown with Uniform manifold approximation and projection (UMAP) visualization approach. (E) Dot plot depicting gene pairs between microglia and OLGs, along with all their co-occurring cell–cell interactions. DEGs for each subcluster in aged were used. Dot size represented the strength of gene pairs using the sum of log2 fold change of related genes and dot color meant the aggregated confidence for gene pairs.

Abbreviations: CNS, central nervous system; MG, microglia; OLGs, oligodendrocytes; DEGs, differentially expressed genes; GO, gene oncology.