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. 2021 Dec 11;14:6813–6831. doi: 10.2147/JIR.S338242

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© 2021 Luan et al.

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Cell–cell interactions between aged microglia and OPCs. (A) Dot plot depicting differentially expressed receptor genes in OPC C1 compared with other subclusters. Receptors (|log2 fold change| > 0.1 and Bonferroni adjusted P-value < 0.05) were colored, red for upregulation and green for downregulation. (B) Heatmap showing the aging-related expression changes of those receptors marked by red in panel (A). (C) Violin plot depicting expression of receptors which were upregulated along with aging in panel (B) and differentially expressed in OPC C1 subset compared with other OPC subsets and OLGs. (D) Heatmap of part of gene ontology (GO) terms related to myelination in which the receptors in panel (C) were involved. (E) Network plot showing the interactions between extracellular ligands from microglia C3 subset and receptors in panel (C). Red for receptors and blue for ligands.

Abbreviations: OPCs, oligodendrocyte precursor cells; OLGs, oligodendrocytes.