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. 2021 Dec 11;14:6799–6812. doi: 10.2147/JIR.S329020

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© 2021 Xie et al.

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MLT alleviates vascular aging-related endothelial injury in ApoE^−/− mice. Young-male ApoE^−/− mice and aged-male ApoE^−/− mice were received high fat diet (HFD) to induce atherosclerosis and intraperitoneally injected with melatonin (MLT; 20 mg/kg/d) for treatment. (A) H&E staining of intima of aorta, magnification×200. (B) TUNEL staining of intima of aorta, magnification×200. (C) Western blot and statistical analysis of protein expression of Bax, Bcl-2 and cleaved caspase3. N=3. *, **, ***p<0.05, 0.01, 0.001.