Table 3.
Univariate and Multivariate Cox Analysis for OS in Skull Base Chordoma
| Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (>55 versus ≤55years) | 1.852 | 1.072–3.198 | 0.027* | 1.945 | 1.117–3.387 | 0.019* |
| Gender (female versus male) | 0.975 | 0.613–1.551 | 0.916 | |||
| Tumor volume (>20 versus ≤20cm3) |
1.697 | 1.056–2.728 | 0.029* | NA | NA | 0.466 |
| Tumor texture (tough/moderate versus soft) |
1.612 | 0.935–2.780 | 0.086 | NA | NA | 0.468 |
| Blood supply (abundant versus poor/moderate) | 1.912 | 1.149–3.182 | 0.013* | 1.920 | 1.147–3.214 | 0.013* |
| Pathology (classical versus chondroid) | 2.027 | 1.162–3.536 | 0.013* | 1.825 | 1.044–3.185 | 0.035* |
| Al-Mefty classification (type III versus type I and II) | 1.876 | 1.178–2.988 | 0.008* | NA | NA | 0.064 |
| Brainstem involvement (yes versus no) | 1.013 | 0.630–1.629 | 0.956 | |||
| Posterior cranial nerve involvement (yes versus no) | 1.287 | 0.802–2.064 | 0.295 | |||
| Extent of resection (non-total versus total resection) | 3.390 | 1.552–7.405 | 0.002* | 3.807 | 1.728–8.387 | 0.001* |
| Postoperative radiotherapy (yes versus no) | 0.794 | 0.479–1.317 | 0.371 | |||
| Hb (<120 versus ≥120 g/L) | 1.118 | 0.450–2.776 | 0.810 | |||
| MCV (<84.2 versus ≥84.2 fl) | 1.980 | 1.085–3.613 | 0.026* | NA | NA | 0.405 |
| RDW (≥12.7 versus <12.7%) | 2.404 | 1.473–3.924 | <0.001* | 2.757 | 1.675–4.539 | <0.001* |
Note: *Indicate p < 0.05.
Abbreviations: OS, overall survival; HR, hazard ratio; CI, confidence interval; NA, not acquired; Hb, hemoglobin; MCV, mean corpuscular volume; RDW, red cell distribution width.