Table 2.

Change of annual notification rate of new syphilis diagnoses per 100,000 people in Guangdong, China, 2004–2019 (N = 641,665).

	Aged ≥50 years			Aged 15–49 years
	ANR (2004–2019)	AAPC (95% CI)	P-value	ANR (2004–2019)	AAPC (95% CI)	P-value
By geography
All cities	13.8–112.0	16.2 (13.7, 18.7)	<0.05	16.9–48.1	6.4 (2.6, 10.3)	<0.05
The pearl river delta area	17.2–109.0	14.7 (9.9, 19.7)	<0.05	25.0–53.2	4.0 (−1.8, 10.1)	<0.05
Eastern cities	8.0–98.8	23.7 (20.4, 27.1)	<0.05	3.7–36.7	16.3 (14.8, 17.8)	<0.05
Western cities	8.9–128.7	20.6 (14.5, 26.9)	<0.05	4.9–34.8	14.3 (10.4, 18.3)	<0.05
Northern cities	14.0–130.5	17.5 (13.6, 21.5)	<0.05	14.8–46.7	6.7 (5.1, 8.3)	<0.05
By gender
Male	20.0–144.0	15.0 (12.4, 17.6)	<0.05	14.9–39.8	5.9 (1.8, 10.1)	<0.05
Female	7.7–80.4	18.6 (15.8, 21.5)	<0.05	18.9–57.3	6.0 (3.1, 8.9)	<0.05
By stage
Primary	6.1–3.3	−3.4 (−7.5, 0.8)	<0.05	6.3–3.2	−7.5 (−10.8, −4.2)	<0.05
Secondary	4.9–1.6	−6.0 (−11.5, −0.1)	<0.05	6.0–4.0	−3.9 (−7.4, −0.3)	<0.05
Tertiary	0.2–0.8	9.6 (3.5, 16.0)	<0.05	0.0–0.2	-	-
Latent	2.6–106.3	28.4 (22.9, 34.1)	<0.05	4.5–40.8	14.4 (8.1, 21.1)	<0.05

ANR, annual notification rate; AAPC, average annual percent change.