Table 4.
Summary of adoptive cell therapy (ACT) for colorectal cancer (CRC).
| Regimen | Target population | Design | Registration number | Status |
|---|---|---|---|---|
| TILs | Malignant Solid Neoplasm including MCRC Adenocarcinoma, Metastatic Ovarian Carcinoma | Phase II | NCT03610490 | Active, not recruiting |
| CRC stage III | Phase I/II | NCT03904537 | Recruiting | |
| CRC | / | NCT02980146 | Completed | |
| CEA-CAR-T | CRC stage III, CRC liver metastasis | Phase I | NCT04513431 | Not yet recruiting |
| Solid cancers including CRC | Phase I, II | NCT04348643 | Recruiting | |
| CRC Peritoneal Carcinomatosis Peritoneal Metastases Gastric Cancer Breast Cancer Pancreas Cancer |
Phase I | NCT03682744 | Active, not recruiting | |
| CART72 | mCRC | Phase I | CC-9701 and CC-9702 clinical trials by Cell Genesys and Aventis Pharmaceuticals | Completed |
| CIK | CRC | Phase IV | NCT03084809 | Completed |
| DC-CIK | CRC | Phase II, III | NCT02419677 | Completed |
| CRC | Phase II, III | NCT02415699 | Unknown | |
| CRC | Phase II | NCT02202928 | Unknown |