Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Signal transduction pathways leading to DNA repair and checkpoint induction by PARP-1 and Atm. PARP-1 is activated by breaks in DNA and is likely to recruit XRCC1 and the BER complex on the site of the lesion, allowing efficient DNA repair and cell cycle progression. ATM, a DNA double-stranded break enzyme, phosphorylates p53 specifically to selectively induce G1 arrest via p21 transcription.
