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HIF-1α expression in ischemic stroke is controlled by different mechanisms. NSCs, neural stem cells; HIF-1α, hypoxia-inducible factor-1α; ACSL4, acyl CoA synthase long chain family member 4; NLRP3, NLR family containing pyrin domain protein 3; IL-18, interleukin 18; IL-1B, interleukin 1B; EPO, erythropoietin; VEGF, vascular endothelial growth factor; NIX, Bcl-2 family proteins containing BH3 domain; BNIP3, BCL2/adenovirus E1B interacting protein 3.
