Fig. 5.
The serum 25‐OH‐D3/24,25‐(OH)2D3 ratio (VMR) in various patient groups (from Kaufmann et al.( 27 )). Patients with biallelic mutations of CYP24A1 show elevated VMRs above 80, while heterozygous relatives of IIH patients and normal individuals with 25‐OH‐D3 >20 ng/mL have VMR values in the normal range of 5 to 25 ng/mL. Individuals with 25‐OH‐D3 <20 ng/mL and classified as vitamin D–deficient as well as stage 5 CKD patients on dialysis show an elevated VMR above the normal range of 5 to 25 ng/mL.