. 2021 Nov 18;5(12):e10569. doi: 10.1002/jbm4.10569

Table 1.

Overview of the Cell Types Expressing Vitamin D Receptor (VDR), 25‐Hydroxylase (CYP24A1), 1α‐Hydroxylase (CYP27B1), or 1,25 Dihydroxyvitamin D (1,25(OH)2D)

Cell types	VDR	CYP24A1	CYP27B1	1,25(OH)2D
Alveolar type 2 cells	X⁽ ¹ ⁾	X⁽ ⁵¹ ⁾	X⁽ ⁵¹ ⁾
Airway epithelial cells	X⁽ ² , ³ ⁾ Apically⁽ ³ ⁾	X⁽ ² , ³ , ⁸ ⁾	X⁽ ² , ³ , ⁸ ⁾	Constitutively⁽ ⁸ ⁾
Lung fibroblasts	X⁽ ⁴ ⁾
Airway smooth muscle cells	X⁽ ⁵ , ⁶ ⁾	X when stimulated with 1,25(OH)2D⁽ ⁵ ⁾
Alveolar macrophages	X⁽ ⁷ ⁾	Non‐functional form⁽ ⁵⁵ ⁾	X⁽ ⁹ ⁾	X when stimulated⁽ ⁵² , ⁵³ , ⁵⁴ ⁾
Neutrophils	X⁽ ⁵⁶ ⁾
Monocytes	X⁽ ⁵⁶ ⁾
NK cells	X⁽ ⁵⁷ ⁾	X⁽ ⁵⁷ ⁾	X⁽ ⁵⁷ ⁾
Eosinophils	X⁽ ⁵⁸ ⁾
Mast cells	X⁽ ⁵⁸ ⁾		X⁽ ⁵⁹ ⁾	X⁽ ⁵⁹ ⁾
Dendritic cells			X⁽ ⁶⁰ , ⁶¹ ⁾	Low⁽ ⁶⁰ , ⁶¹ ⁾
T lymphocytes	X⁽ ⁶² ⁾
B lymphocytes	X⁽ ⁶³ ⁾		X⁽ ⁶⁴ ⁾	X⁽ ⁶⁴ ⁾