Clinical studies with CMR-assessed cardiac fibrosis in SCD (SCA, HbSC, HbS-thalassemia). CMR, cardiac magnetic resonance; SCD, sickle cell disease.
Definitions: N, number of study participants; %, percentage of study participants with the feature; Mass/Diam, mass or diameter; LVDD, left ventricular diastolic dysfunction; LVEF, left ventricular ejection fraction (PEF, preserved ejection fraction; REF, reduced ejection fraction); LGE, late gadolinium enhancement; ECV, extracellular volume; T, increased versus normal; 4-, decreased versus normal; RA, right atrium; RV, right ventricle; LA, left atrium; LV, left ventricle; na, no available data.