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Structural disruption is dependent on both base and position. (A) FRET histograms of each DNA construct before (gray) and after (cyan) incubation for 5 min with the complementary C strand (CCCTAA)4. High FRET converts to low FRET upon annealing as an indicator of accessibility. (B) Sample single-molecule traces of a telomeric construct harboring an 8oxoG at the G1 position displaying the three major types of molecular behavior.
