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Complementary strand and POT1 binding reflect the structural instability of the telomeric G-quadruplex. (A) FRET state classification as the fractional distribution of folded (black), partially unfolded (green), and unfolded (red) populations. (B and C) Plots of the fraction of single-molecule traces displaying dynamic FRET or steady unfolded state (FRET < 0.6) vs the fraction of molecules bound to (CCCTAA)4 or POT1, respectively.
