Table 1.
TR-241 | TR-243 | TR-247 | |
---|---|---|---|
Demographicsa | |||
Age in years, Sex | 43, male | 44, male | 49, female |
COVID-19 history | |||
Timing prior to TB diagnosis | 3 months | 6 months | 4 months |
Anti-SARS-CoV-2 IgG at TB diagnosisb | Positive | Positive | Positive |
Symptoms at the time of the COVID-19 episode: | |||
Cough | Yes | Yes | Yes |
Fever, chills | Yes | Yes | Yes |
Fatigue | Yes | Yes | Yes |
Loss of smell and taste | Yes | Yes | Yes |
Shortness of breath | Yes | No | No |
Body aches | Yes | Yes | No |
Duration of TB signs and symptoms prior to reporting to the TB clinic (days) | |||
Cough | 90 | 180 | 120 |
Productive cough | 60 | 90 | 60 |
Fever, chills | 14 | 15 | 14 |
Chest pain | 3 | N/R | N/R |
Weight loss | 60 | 60 | 60 |
Fatigue | N/R | N/R | 30 |
TB diagnosis | |||
Acid-fast bacilli smear grade (bacilli/field) | > 10 | > 10 | > 10 |
M. tuberculosis culturec | Positive | Positive | Positive |
TB risk factors and other medical conditions | |||
Body mass index | 13.4 | 23.7 | 29 |
BCG vaccine | Yes | Yes | Yes |
HIV | Negative | Negative | Negative |
Smoking | No | No | No |
Alcohol excess and illicit drugsd | No | Yes | No |
Type 2 diabetes | Yes | Yes | Yes |
Years with type 2 diabetes | 13 y | 5 y | 6 y |
HbA1c | 8.2% | 7.5% | 10.6% |
Fasting blood glucose (mg/dl) | 105 | 138 | 126 |
Diabetes medicationse | Metformin | No | Glibenclamide metformin |
Other medical conditions | Peripheral neuropathy | None | High blood pressure |
History of past TB or TB exposure | |||
Self-reported past exposure to a TB patient | No | No | Yes, > 2 years ago |
Prior testing for latent TB infection | No | No | No |
Past history of active TB | No | No | No |
N/R symptom not reported, TB tuberculosis, SARS-CoV-2 SARS coronavirus 2, COVID-19 coronavirus disease 2019, HIV Human immunodeficiency virus, HbA1c hemoglobin A1c
aAll are Hispanic, White
bAnti-SARS-CoV-2 IgG assay, Abbott Laboratories, Abbott Park, IL
cM. tuberculosis spp. identified with BioLine MPT64 Rapid, Standard Diagnostics, Korea
dTR-243: > 10 drinks and cocaine on weekends
eTR-247: metformin 1700 mg/d; TR-249: Metformin 500 mg/d and glibenclamide 2.5 mg/day