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Regulation of Th17 cell differentiation by CTRP3 through AdipoR2. CTRP3 mainly expressed in dendritic cells and Th17 cells regulates Th17 cell differentiation through activation of AdipoR2, but not via AdipoR1. The CTRP3/AdipoR2 axis enhances PPARα expression and inhibits STAT3 and RORγt expression.
