Table 2.
Principal laboratory findings at baseline.
| Mild (n = 23) | Moderate (n = 28) | Severe (n = 9) | p-value a | Post-test p-value b | |
|---|---|---|---|---|---|
| WBC (109/L), median [IQR] | 6.1 [4.5 - 7.2] | 5.65 [3.95 - 8.25] | 9.7 [9 - 11] | 0.013 | Mo vs. S: 0.008 Mi vs. S: 0.011 |
| Neutrophil (109/L), median [IQR] | 3.7 [2.52 - 5.2] | 4.1 [2.35 - 6.5] | 9.1 [7.8 - 10.1] | 0.001 | Mo vs. S: 0.002 Mi vs. S: <0.001 |
| Neutrophil %, median [IQR] | 66.6 [51.2 - 75.1] | 74.9 [64.3 - 79.95] | 89.5 [87.1 - 91.6] | <0.001 | Mo vs. S: <0.001 Mi vs. S: <0.001 |
| Lymphocytes (109/L), median [IQR] | 1.3 [1 - 1.8] | 0.95 [0.8 - 1.35] | 0.5 [0.4 - 0.6] | <0.001 | Mo vs. S: 0.01 Mi vs. S: <0.001 |
| Lymphocytes %, median [IQR] | 22.6 [17.6 - 32.3] | 15.35 [11.4 - 26.45] | 5.2 [3.9 - 6.5] | <0.001 | Mo vs. S: <0.001 Mi vs. S: <0.001 |
| Monocytes (109/L), median [IQR] | 0.5 [0.3 - 0.7] | 0.5 [0.3 - 0.75] | 0.4 [0.2 - 0.6] | ns | |
| Monocytes %, median [IQR] | 8.7 [5.8 - 10.1] | 8.5 [6.95 - 10.95] | 3.5 [3.3 - 4] | <0.001 | Mo vs. S: <0.001 Mi vs. S: <0.001 |
| CRP (mg/L), median [IQR] | 47.2 [26.15 - 74.52] | 92.9 [21.65 - 145.5] | 124.3 [109.6 - 132] | 0.015 | Mi vs. S: 0.008 |
| Ferritin (microg/L), median [IQR] | 275.1 [87.6 - 757.5] | 398.5 [183 - 722.8] | 1110 [100 - 1486] | ns | |
| IL-6 (pg/ml), median [IQR] | 17.36 [8.96 - 37.84] | 26.24 [8.64 - 67.48] | 67.12 [31.24 - 99.66] | 0.048 | Mi vs. S: 0.023 |
| Creatinine (µmol/L), median [IQR] | 74 [67 - 117] | 74.5 [64 - 90.5] | 108 [106 - 119] | 0.012 | Mo vs. S: 0.005 Mi vs. S: 0.023 |
| D-Dimer (µg/L), median [IQR]c | 835 [487 - 1530] | 1038 [496.5 - 2357] | 2482 [1241 - 5400] | ns | |
| ACE (U/L)d | 26.8 [19.7 - 31.5] | 25.2 [5.3 - 39.1] | 17.6 [17.7 - 25.6] | ns | |
| RT-qPCR Ct, median [IQR] e | 25 [21 - 32] | 25 [23 - 31] | 24 [19 - 30] | ns | |
| IgM-S (positive), n (%)f | 12 (52.2%) | 15 (53.6%) | 7 (77.8%) | ns | |
| IgG-N (positive), n (%)f | 9 (39.1%) | 16 (57.1%) | 7 (77.8%) | ns |
a
Kruskal-Wallis test for comparison between continuous variables.
b
Dunn post-test with Bonferroni correction, Mi, mild; Mo, Moderate; S, Severe.
c
Missing data for 1 mild patient.
d
Missing data for 2 mild patients.
e
Missing data for 2 mild patients and 2 moderate patients.
f
Missing data for 4 mild patients, 3 moderate patients and 1 severe patient.
IQR, interquartile range; Mild, modified WHO score = 4; Moderate, modified WHO score = 5; Severe, modified WHO score≥6
ns, non significant.