Table 4.
Multivariable logistic regression analysis for the prediction of a clinical aggravation during hospitalisation.
| Parameter | Odds ratio Estimates | Likelihood Ratio test | Hosmer-Lemeshow goodness of fit | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Reference | Odds Ratio | 95% CI | p-value | χ2 | DF | p-value | χ2 | DF | p-value | |
| CD4+ T cells | ≤ 136.7 | 6.471 | 1.513 - 27.673 | 0.012 | 21.756 | 5 | <0.001 | 4.858 | 8 | 0.773 |
| Gender | Female | 0.234 | 0.055 - 0.989 | 0.048 | ||||||
| Age | 1.042 | 0.984 - 1.104 | 0.157 | |||||||
| Comorbidity | No | 1.822 | 0.272 - 12.217 | 0.537 | ||||||
| Treatment | No | 1.939 | 0.410 - 9.160 | 0.403 | ||||||
| Th1 (CCR6-/CXCR3+) | ≤ 18.34 | 7.863 | 1.653 - 37.396 | 0.010 | 24.204 | 5 | <0.001 | 3.834 | 7 | 0.799 |
| Gender | Female | 0.156 | 0.031 - 0.774 | 0.023 | ||||||
| Age | 1.060 | 0.992 - 1.132 | 0.085 | |||||||
| Comorbidity | No | 3.512 | 0.401 - 30.799 | 0.257 | ||||||
| Treatment | No | 1.776 | 0.369 - 8.556 | 0.474 | ||||||
| Th2 (CCR6-/CCR4+) | ≤ 5 | 4.352 | 1.059 - 17.893 | 0.042 | 20.720 | 5 | <0.001 | 3.237 | 7 | 0.862 |
| Gender | Female | 0.105 | 0.023 - 0.479 | 0.004 | ||||||
| Age | 1.047 | 0.986 - 1.112 | 0.135 | |||||||
| Comorbidity | No | 1.696 | 0.257 - 11.191 | 0.583 | ||||||
| Treatment | No | 1.838 | 0.395 - 8.558 | 0.438 | ||||||
| Treg (CD25+/CD127low) | ≤ 30 | 6.807 | 1.571 - 29.495 | 0.010 | 22.357 | 5 | <0.001 | 4.606 | 8 | 0.799 |
| Gender | Female | 0.141 | 0.032 - 0.618 | 0.009 | ||||||
| Age | 1.053 | 0.991 - 1.119 | 0.096 | |||||||
| Comorbidity | No | 2.419 | 0.370 - 15.819 | 0.357 | ||||||
| Treatment | No | 1.826 | 0.397 - 8.409 | 0.440 | ||||||
| PaO2/FiO2 | ≤ 186 | 16.678 | 1.925 - 144.477 | 0.011 | 24.222 | 5 | <0.001 | 10.308 | 8 | 0.244 |
| Gender | Female | 0.110 | 0.023 - 0.529 | 0.006 | ||||||
| Age | 1.032 | 0.974 - 1.093 | 0.285 | |||||||
| Comorbidity | No | 2.064 | 0.308 - 13.848 | 0.456 | ||||||
| Treatment | No | 1.404 | 0.276 - 7.138 | 0.683 | ||||||
Treatment administered during hospitalisation included: hydroxychloroquine; corticosteroids; hydroxychloroquine + antivirals; hydroxychloroquine + corticosteroids; hydroxychloroquine + immunological treatment; hydroxychloroquine + antivirals + corticosteroids; hydroxychloroquine + antivirals + immunological treatment; hydroxychloroquine + antivirals + immunological treatment + corticosteroids.