. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2021 Aug 11;428:115678. doi: 10.1016/j.taap.2021.115678

Table 3.

Concentration expressed in ng/g of tissue 96 h after single exposure of doses of 3, 10, 30, and 100 mg of γ-HBCD/kg of BW. “Exp” corresponds to measured data and “Sim” to the simulated data obtained with the PBPK model.

Tissue	3 mg/kg		10 mg/kg		30 mg/kg		100 mg/kg
Tissue	Exp (±SD) (ng/g)	Sim (ng/g)	Exp (±SD) (ng/g)	Sim (ng/g)	Exp (±SD) (ng/g)	Sim (ng/g)	Exp (±SD) (ng/g)	Sim (ng/g)
Liver	160 ± 15	232	440 ± 90	770	2015 ± 213	2319	6811 ± 1233	7684
Blood	24 ± 1.5	28	90 ± 9.5	94	270 ± 26	283	867 ± 93	938
Adipose tissue	27 ± 5.4	42	146 ± 73	142	625 ± 262	425	2580 ± 890	1418
Brain	24 ± 3.0	34	73 ± 10	113	248 ± 28	338	808 ± 101	1129