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. 2021 Dec 2;12:744573. doi: 10.3389/fimmu.2021.744573

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Copyright © 2021 Santamaria, Desmots, Leonard, Caron, Haas, Delaloy, Chatonnet, Rossille, Pignarre, Monvoisin, Seffals, Lamaison, Cogné, Tarte and Fest

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell destiny of human LZ B_GC-cells after Tfh-like stimulation. (A) The experimental plan, with five different cell populations (colored script) analyzed using sc-RTqPCR. (B) The UMAP representation (colored according to the experimental conditions) highlighted two different fates as a function of CD23 expression. (C) Projection of B cell identity genes (BCL6 and PAX5) and PC identity genes (PRDM1, XBP1, and IRF4) onto the UMAP representation. (D) The UMAP representation (colored according to the Monocle pseudotime), showing an ordered, progression in four quadrants from LZ B_GC-cells to PBs.