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. 2021 Dec 1;23(1):99. doi: 10.3892/etm.2021.11022

Figure 6.

Figure 6

EZH2 overexpression reverses the increased cell migration and angiogenesis induced by HOTAIR silencing. (A) Analysis of hBMVEC invasion using a Transwell assay. Magnification, x100. (B) Measurement of tube formation capabilities of hBMVECs. Magnification, x40. ***P<0.001 vs. Control, ###P<0.001 vs. OGD/R 24 h + siRNA-NC, and ∆∆P<0.01 and ∆∆∆P<0.001 vs. OGD/R 24 h + siRNA-HOTAIR + Ov-NC. HOTAIR, Hox transcript antisense intergenic RNA; EZH2, enhancer of zeste homolog 2; si, small interfering RNA; OGD/R, oxygen-glucose deprivation/reperfusion; NC, negative control; Ov, overexpression; NC, negative control; hBMVECs, human brain microvascular endothelial cells.