Table 3.
Genetic predisposition to pain and risk of major depression disorder: the results from Mendelian randomization analysis.
| Methods | # SNP | OR (95% CI) | P | P for intercept or heterogeneity | # SNP | OR (95% CI) | P | P for intercept or heterogeneity | # SNP | OR (95% CI) | P | P for intercept or heterogeneity |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Full set | Remove SNPs associated with confounding traits | Remove palindromic SNPs | ||||||||||
| Multisite chronic pain on MDD | ||||||||||||
| IVW | 37 | 1.78 (1.51-2.11) | 1.6 × 10 −11 | < 0.001 | 26 | 1.67 (1.40-1.98) | 8.9 × 10 −9 | < 0.001 | 34 | 1.78 (1.49-2.12) | 2.4 × 10 −10 | < 0.001 |
| MR-Egger | 37 | 1.60 (0.68-3.79) | 0.28 | 0.81 | 26 | 2.28 (0.88-5.94) | 0.19 | 0.52 | 34 | 1.57 (0.65-3.80) | 0.32 | 0.78 |
| Weighted median | 37 | 1.48 (1.27-1.73) | 8.3 × 10 −7 | 26 | 1.48 (1.22-1.79) | 5.4 × 10 −5 | 34 | 1.48 (1.26-1.74) | 1.9 × 10 −6 | |||
| Headache on MDD | ||||||||||||
| IVW | 26 | 1.55 (1.13-2.10) | 0.005 | < 0.001 | 20 | 1.77 (1.18-2.66) | 0.005 | < 0.001 | 23 | 1.35 (1.06-1.70) | 0.01 | 0.02 |
| MR-Egger | 26 | 0.77 (0.30-1.98) | 0.59 | 0.14 | 20 | 0.59 (0.16-2.16) | 0.44 | 0.10 | 23 | 0.77 (0.39-1.53) | 0.47 | 0.11 |
| Weighted median | 26 | 1.42 (1.07-1.88) | 0.01 | 20 | 1.77 (1.25-2.49) | 0.001 | 23 | 1.41 (1.07-1.85) | 0.01 | |||
CI, confidence interval; IVW, inverse variance-weighted; MDD, major depression disorder; MR, Mendelian randomization; OR, odds ratio.