Figure 4.

Olorinab had no effect on colonic nociceptors from healthy mice. (A) The mechanosensitive response of colonic nociceptors from healthy mice was unaffected by increasing concentrations of olorinab. Comparisons were performed using a one-way ANOVA followed by the Bonferroni post hoc test (P > 0.05). (B) The change in baseline response of healthy nociceptors in the presence of increasing concentrations of olorinab indicated no effect of olorinab on nociceptor firing even at high concentrations. (C) Single-unit colonic nociceptor recordings from healthy mice showed mechanical responsiveness was unchanged with olorinab application. Data are presented as mean ± SEM. ANOVA, analysis of variance; vfh, von Frey hair.