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. 2021 Dec 2;9:788422. doi: 10.3389/fcell.2021.788422

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Copyright © 2021 Zhao, Mei, Shang, Zou, Lian, Xu, Wu, Lai, Liu, Wei, Zhu, Zhang, Liu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lens opacity caused by LssG589S/G589S mutation was formed at the embryonic stage. Examination of lens transparency in WT, Lss^G589S/+, and Lss^G589S/G589S mice at (A) E18.5, (B) E17.5, (C) E16.5, (D) E15.5, and (E) E14.5 by stereomicroscopy. White arrows indicate that mild cataract was formed at E17.5 and serious cataract was formed at E18.5 in the lens of Lss^G589S/G589S mice. Black arrows indicate that no visible cataract was observed at E14.5, E15.5, and E16.5 in the lens of Lss^G589S/G589S mice.