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. 2021 Dec 2;9:788422. doi: 10.3389/fcell.2021.788422

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Copyright © 2021 Zhao, Mei, Shang, Zou, Lian, Xu, Wu, Lai, Liu, Wei, Zhu, Zhang, Liu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disrupted polarity of lens fiber cells in Lss^G589S/G589S mice. (A) Alignment of lens fiber cells stained with hematoxylin and eosin and distribution of cell nuclei in sagittally sectioned lenses in the equator plane of WT, Lss^G589S/+, and Lss^G589S/G589S mice at E14.5. Scale bar: 80 μm. The enlargement is the magnification of the boxed inset shown in the upper panel. Scale bar: 20 μm. (B) The expression of ZO-1 in lens of WT, Lss^G589S/+, and Lss^G589S/G589S mice at E14.5. Scale bar: 40 μm. The enlargement is the magnification of the boxed inset shown in the upper panel. Red arrows indicate lens fulcrums. White arrow indicates that ZO-1 was strongly retained in the zones between lens fiber cells of Lss^G589S/G589S mice. Scale bar: 10 μm.