Table I.

Changes in expression of genes that affect B cell functions in Runx1 c-k/o measured by RNA-seq analysis of resting B cells and after 3-h activation with anti-IgM + IL-4

Gene	Base Mean	Fold Change 0 h	Fold Change 3 h	Functions	References
Ptpn22	995	1.3 ↓	1.9 ↓	Phosphatase; regulates SRC-family kinase; negative regulator of BCR signaling and B cell apoptosis	Armitage et al. (79)
Lrrk2	6056	1.7 ↓	3.7 ↓	Kinase; involved in regulation of B cell homeostasis	Kubo et al. (80)
Ccr6	974	3.0 ↓	4.0 ↓	Chemokine receptor; expressed on naive and memory B cells	Krzysiek et al. (81), Bowman et al. (82)
Cd22	11,926	1.2 ↓	1.4 ↓	Inhibitory coreceptor; negative regulator of BCR signaling	O’Keefe et al. (74), Müller and Nitschke (83)
Irf7	1046	2.0 ↑	3.5 ↑	Regulation of IFN response gene transcription	Ning et al. (84)
Irf5	3126	1.1 ↑	1.4 ↑	Regulation of IFN response gene transcription	Ban et al. (85)
Ifnar1	4324	2.5 ↑	1.9 ↑	Subunit of IFN-α receptor	Pogue et al. (86)
Zbp1	787	1.1 ↑	2.1 ↑	Encodes DNA-dependent activator of IFN-regulatory factors	Takaoka et al. (87)
Trib1	1081	1.1 ↑	1.9 ↑	Negative regulator of Ab production	Simoni et al. (88)
Lgals9	1512	1.2 ↑	1.7 ↑	Negative regulator of BCR signaling	Cao et al. (66)
Stat1	3506	1.0 ↑	1.5 ↑	Enhancement of IFN-induced gene expression	Cheon et al. (89)
Tnfrsf13c	4888	1.2 ↑	1.4 ↑	Encodes BAFF receptor; promotes survival of FO and MZ B cells	Thompson et al. (90), Schiemann et al. (91)
Bank1	7290	1.0 ↑	1.3 ↑	Inhibition of CD40- and BCR-mediated activation of B cells	Aiba et al. (92)

Adjusted p values for all differences shown < 0.05 (see Supplemental Tables I and II for the full set of base mean values). Arrows indicate fold downregulation (↓) or upregulation (↑) in the Runx1 c-k/o B cells.