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. 2021 Dec 15;207(12):2976–2991. doi: 10.4049/jimmunol.2001367

Table I.

Changes in expression of genes that affect B cell functions in Runx1 c-k/o measured by RNA-seq analysis of resting B cells and after 3-h activation with anti-IgM + IL-4

Gene Base Mean Fold Change 0 h Fold Change 3 h Functions References
Ptpn22 995 1.3 ↓ 1.9 ↓ Phosphatase; regulates SRC-family kinase; negative regulator of BCR signaling and B cell apoptosis Armitage et al. (79)
Lrrk2 6056 1.7 ↓ 3.7 ↓ Kinase; involved in regulation of B cell homeostasis Kubo et al. (80)
Ccr6 974 3.0 ↓ 4.0 ↓ Chemokine receptor; expressed on naive and memory B cells Krzysiek et al. (81), Bowman et al. (82)
Cd22 11,926 1.2 ↓ 1.4 ↓ Inhibitory coreceptor; negative regulator of BCR signaling O’Keefe et al. (74), Müller and Nitschke (83)
Irf7 1046 2.0 ↑ 3.5 ↑ Regulation of IFN response gene transcription Ning et al. (84)
Irf5 3126 1.1 ↑ 1.4 ↑ Regulation of IFN response gene transcription Ban et al. (85)
Ifnar1 4324 2.5 ↑ 1.9 ↑ Subunit of IFN-α receptor Pogue et al. (86)
Zbp1 787 1.1 ↑ 2.1 ↑ Encodes DNA-dependent activator of IFN-regulatory factors Takaoka et al. (87)
Trib1 1081 1.1 ↑ 1.9 ↑ Negative regulator of Ab production Simoni et al. (88)
Lgals9 1512 1.2 ↑ 1.7 ↑ Negative regulator of BCR signaling Cao et al. (66)
Stat1 3506 1.0 ↑ 1.5 ↑ Enhancement of IFN-induced gene expression Cheon et al. (89)
Tnfrsf13c 4888 1.2 ↑ 1.4 ↑ Encodes BAFF receptor; promotes survival of FO and MZ B cells Thompson et al. (90), Schiemann et al. (91)
Bank1 7290 1.0 ↑ 1.3 ↑ Inhibition of CD40- and BCR-mediated activation of B cells Aiba et al. (92)

Adjusted p values for all differences shown < 0.05 (see Supplemental Tables I and II for the full set of base mean values). Arrows indicate fold downregulation (↓) or upregulation (↑) in the Runx1 c-k/o B cells.