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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Alcohol. 2020 Nov 4;91:21–27. doi: 10.1016/j.alcohol.2020.10.005

Figure 2. Bidirectional modulation of NAc core activity alters binge-like EtOH drinking in male C57BL/6J mice.

Figure 2.

(A) CNO treatment resulted in differences in intake between male mice expressing hM4Di and hM3Dq (and hM4Di and GFP) in the NAc core (two-way ANOVA with Tukey’s HSD; ***p < 0.001). (B) EtOH intake presented as average individual difference scores (=intake during treatment with CNO – intake during treatment with vehicle) shows bidirectional modulation of binge-like drinking in mice expressing hM4Di as compared with hM3Dq (one-way ANOVA with Tukey’s HSD; **p < 0.01). n = 11-15/viral group.