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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Alcohol. 2020 Nov 4;91:21–27. doi: 10.1016/j.alcohol.2020.10.005

Figure 3. Influence of bidirectional modulation of NAc core activity on water and tastants.

Figure 3.

(A) CNO increased quinine intake in mice expressing hM3Dq in the NAc core as compared to hM4Di or GFP at the higher concentration of 0.06 mM, but not at 0.03 mM (two-way ANOVA with Tukey’s HSD; **p < 0.01, *** p < 0.001). (B) There was no effect of CNO/DREADDs on sucrose consumption at either concentration, but mice from all groups consumed more of the 5% sucrose concentration than the 2.5% concentration (two-way ANOVA wirh Tukey’s HSD; ****p<0.0001). (C) CNO increased water intake for mice expressing hM3Dq in the NAc core as compared to hM4Di or GFP expressing mice on days 3 and 4 (two-way mixed factor ANOVA with Tukey’s HSD; ^p<0.05 hM3Dq vs GFP; *p<0.05 hM3Dq vs hM4Di; **p<0.01 hM3Dq vs hM4Di). n = 11-15/viral group