Table 1:

Differentially abundant plasma biomarkers

	Ts+4 vs T0			Ts vs T0			T4 vs T0 (Outgrown)
	P value	Difference	q value	P value	Difference	q value	P value	Difference	q value
REG1A	0.00000	1.649	0.000	0.0479	0.4157	>0.99	0.945	0.014	>0.99
IL-17A	0.00000	3.879	0.000	0.00008	3.042	0.004	0.0623	0.814	>0.99
CCL20	0.00004	3.888	0.002	0.01238	2.399	0.145	0.1227	0.960	>0.99
IL-17C	0.00006	4.648	0.002	0.21497	1.028	0.963	0.1153	0.682	>0.99
IL8	0.00017	2.809	0.004	0.00001	3.498	0.001	0.0220	0.913	0.839
CXCL9	0.00193	1.450	0.021	0.53305	0.172	0.963	0.8391	−0.059	>0.99
IL10	0.00152	1.664	0.021	0.18411	0.376	0.950	0.5412	0.175	>0.99
IL2	0.00183	2.271	0.021	0.00064	1.722	0.020	0.3822	0.126	>0.99
IL6	0.00161	1.779	0.021	0.03533	1.198	0.289	0.0063	1.588	0.611
OSM	0.00223	1.769	0.021	0.52136	0.331	0.963	0.8642	−0.062	>0.99
LIF	0.00295	0.614	0.025	0.01899	0.191	0.177	0.1598	0.394	>0.99
CCL25	0.00672	0.740	0.048	0.26773	0.254	0.963	0.9124	−0.023	>0.99
TNF	0.00673	0.767	0.048	0.00721	0.729	0.120	0.9850	0.014	>0.99
HGF	0.00761	0.591	0.050	0.44960	0.134	0.963	0.2414	−0.131	>0.99
CCL4	0.00982	1.152	0.056	0.00773	1.299	0.120	0.7342	0.094	>0.99
TGF-a	0.00981	1.359	0.056	0.16102	0.450	0.950	0.9260	−0.023	>0.99
CCL3	0.02001	0.923	0.108	0.01488	1.028	0.155	0.5454	0.150	>0.99
CXCL1	0.03006	0.729	0.152	0.01185	0.781	0.145	0.6001	−0.161	>0.99
MCP-1	0.04146	1.061	0.198	0.00479	1.358	0.112	0.2082	0.382	>0.99

Difference = normalized protein units (Log2 scale). Significant values bolded. T0 = baseline, Ts = Time of symptoms, Ts+4 = 4 hours after symptoms. In asymptomatic (outgrown) challenges, a single post-challenge sample was obtained 4 hours after challenge (T4).