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. 2021 Dec 8;6(23):e154350. doi: 10.1172/jci.insight.154350

Figure 1. The complete model of the CTF.

Figure 1

(A) Actin (gray), Tm (orange and green), cTnC (red), cTnI (blue), and cTnT (yellow). The zoomed-in view of region B (B) containing Tm (residues 160–230) and the unstructured linker region of cTnT (residues 155–220). The zoomed-in view of region A (C) containing the overlap region (cTnT 80–150; Tm 1–50, 250–284) where Tm dimers overlap in a head-to-tail fashion. (D) The overlap region of the CTF along with the center of mass of the respective helices (black dots) used to calculate the distances between proteins. Four specific cTnT residues are labeled, with arrows showing the closest Tm residue used to calculate the overlap distance and distribution plots.