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. 2021 Dec 8;6(23):e149699. doi: 10.1172/jci.insight.149699

Figure 2. IL-33 induces inflammation and alters endometriosis lesion microenvironment in a murine model.

Figure 2

(A) Representative images show exogenous IL-33 (n = 5) aggravates the lesion and contributes toward a larger, highly vascularized lesion compared with PBS-treated controls (n = 5). (B) Schematic representation of the experimental outline shows the induction of endometriosis (day 0), i.p. injections of either exogenous IL-33 or PBS on alternative days (beginning on day 11), and euthanasia (day 25). (C) Cytokines and chemokines from the peritoneal lavage fluid of PBS-treated and IL-33–treated mice were analyzed using a multiplex cytokine analysis. (D) Peritoneal lavage cells were harvested from PBS- and IL-33–treated EMS mice and counted using a Countess II FL Automated Cell Counter. **P < 0.01, ***P < 0.001. Mean ± SD. Nonparametric Student’s t test with Mann-Whitney.