(A) Age and disease duration at study entry. (B) Disease location at diagnosis. L1, terminal ileum; L2; colon; L3, ileocolonic. (C) Disease behavior. B1, nonstricturing, nonpenetrating; B2, stricturing; B3, penetrating. (D) Disease activity. (E) Extraintestinal manifestations (EIM). (F) Resistance (RE) to biologic therapy. (G) The number of patients who received thiopurine or anti-TNF therapy. (A) Results are shown as mean ± SD. Dots indicate individual participants, as do numbers within bars. P values by Mann-Whitney U test (A) and Fisher exact test (B–G) are shown.