Figure 7. mTOR-dependent epileptogenesis affects the hippocampal transcriptome.

(A) Experimental group conditions of the RNA-Seq samples. All groups included 4 mice. (B) Principal component analysis (PCA) plot of all mice included in the RNA-Seq analysis showing the variation between and within conditional groups. (C–F) Volcano plots showing the significance of upregulated (red) and downregulated (blue) genes of Tsc1-Cre⁺ day 4, Tsc1-Cre⁺ day 6, Tsc1-Cre⁺ day 8, and Tsc1-Cre⁺ day 13 mice compared with Tsc1-Cre^– mice.