Figure 8. Shorter treatment regimens of STm^ΔaroA yield similar protection.

(A) AOM/DSS CAC was induced as per Figure 1A in female C57B6/J mice. Mice were then split into no treatment (NT, PBS control) and 1 or 6 doses of STm^ΔaroA (given once per week via oral gavage). The left is survival from treatment start point (P = 0.0184 Mantel-Cox log-rank test), the middle is the tumor burden, and the right is tumor load. (B) Apc^min/+ mice were treated from 9 weeks of age with either PBS control (NT), 2 doses of STm^ΔaroA (with PBS control for remaining 4 weeks), or 6 doses of STm^ΔaroA. The left is survival (Mantel-Cox log-rank test), the middle is number of polyps per mouse (small intestine), and the right shows CFU obtained from polyps at necroscopy. Data are shown as mean ± SD.