Table 3.

Clinical features of Sweet syndrome in the cohort

Factor	Overall [N = 95]		AZA group [N = 20]		Non-AZA group [N = 75]		p-value	Cohn’s disease [N = 48]		Ulcerative colitis [N = 43]		p-value
	N	Statistics	N	Statistics	N	Statistics		N	Statistics	N	Statistics
Skin findings, n [%]	91		20		71			46		41
Macules and papules		42 [46.2]		13 [65.0]		29 [40.8]	0.06 c		21 [45.7]		18 [43.9]	0.87 c
Subcutaneous EN-like		2 [2.2]		0 [0.0]		2 [2.8]	1 a		2 [4.3]		0 [0.0]	0.50 a
Plaques		51 [56.0]		11 [55.0]		40 [56.3]	0.92 c		29 [63.0]		21 [51.2]	0.27 c
Pustules		36 [39.6]		9 [45.0]		27 [38.0]	0.57 c		16 [34.8]		19 [46.3]	0.27 c
Pseudo-vesicular		18 [19.8]		4 [20.0]		14 [19.7]	1 a		10 [21.7]		8 [19.5]	0.80 c
Bullous		10 [11.0]		1 [5.0]		9 [12.7]	0.45 a		3 [6.5]		6 [14.6]	0.30 a
Nodular		19 [20.9]		4 [20.0]		15 [21.1]	1 a		10 [21.7]		9 [22.0]	0.98 c
Lesion frequency, n [%]	92		19		73		0.42 a	46		42		0.66 a
Single		5 [5.4]		0 [0.0]		5 [6.8]			2 [4.3]		3 [7.1]
Multiple		87 [94.6]		19 [100.0]		68 [93.2]			44 [95.7]		39 [92.9]
Lesion distribution, n [%]	94		20		74			47		43
Upper limbs		63 [67.0]		12 [60.0]		51 [68.9]	0.45 c		33 [70.2]		29 [67.4]	0.78 c
Dorsum of hands		20 [21.3]		3 [15.0]		17 [23.0]	0.55 a		9 [19.1]		11 [25.6]	0.46 c
Palms		13 [13.8]		4 [20.0]		9 [12.2]	0.46 a		7 [14.9]		6 [14.0]	0.90 c
Lower limbs		58 [61.7]		16 [80.0]		42 [56.8]	0.0 a		33 [70.2]		23 [53.5]	0.10 c
HEENT		52 [55.3]		14 [70.0]		38 [51.4]	0.14 c		22 [46.8]		28 [65.1]	0.08 c
Trunk		54 [57.4]		17 [85.0]		37 [50.0]	0.005 a		27 [57.4]		26 [60.5]	0.77 c
Oral mucosa		24 [25.5]		5 [25.0]		19 [25.7]	0.95 c		14 [29.8]		8 [18.6]	0.22 c
Genital area		1 [1.1]		0 [0.0]		1 [1.4]	1 a		1 [2.1]		0 [0.0]	1 a
Neutrophilia, n [%]	75		16		59		0.12 a	41		32		1 a
Yes		67 [89.3]		16 [100.0]		51 [86.4]			36 [87.8]		29 [90.6]
No		8 [10.7]		0 [0.0]		8 [13.6]			5 [12.2]		3 [9.4]
Elevated ESR, adjusted for age, n [%]	39		8		31		0.20 a	23		16		1 a
Yes		37 [94.9]		7 [87.5]		30 [96.8]			22 [95.7]		15 [93.8]
No		2 [5.1]		1 [12.5]		1 [3.2]			1 [4.3]		1 [6.2]
Anaemia n [%]	60		12		48		0.07 a	31		26		0.39 c
Yes		35 [58.3]		4 [33.3]		31 [64.6]			19 [61.3]		13 [50.0]
No		25 [41.7]		8 [66.7]		17 [35.4]			12 [38.7]		13 [50.0]
Abnormal platelet counts, n [%]	51		11		40		0.32 a	25		24		0.49 a
Yes		3 [5.9]		1 [9.1]		2 [5.0]			2 [8.0]		0 [0.0]
No		48 [94.1]		10 [90.9]		38 [95.0]			23 [92.0]		24 [100.]
CRP level, median [range], mg/dL	44	16.6 [1.4–36.4]	11	16.16 [1.4–30.6]	33	16.8 [7.2–36.4]	0.94 b	27	16.8 [7.2–30.6]	16	13.02 [1.4–30.9]	0.76 b
Pathology variant, n [%]	93		20		73		0.38 a	46		43		0.25 a
Classical		76 [81.7]		19 [95.0]		57 [78.1]			39 [84.8]		34 [79.1]
Histiocytoid		5 [5.4]		0 [0.0]		5 [6.8]			4 [8.7]		1 [2.3]
Subcutaneous		2 [2.2]		0 [0.0]		2 [2.7]			1 [2.2]		1 [2.3]
Bullous		3 [3.2]		1 [5.0]		2 [2.7]			0 [0.0]		2 [4.7]
NDDH		7 [7.5]		0 [0.0]		7 [9.6]			2 [4.3]		5 [11.6]
Successful treatments used, n [%]	95		20		75			48		43
Steroids		86 [90.5]		15 [75.0]		71 [94.7]	0.008 c		42 [87.5]		40 [93.02]	0.49 a
Indomethacin or NSAIDs		3 [3.2]		0 [0.0]		3 [4.0]	1 a		3 [6.25]		0 [0]	0.24 a
Dapsone		4 [4.2]		0 [0.0]		4 [5.3]	0.58 a		2 [4.17]		2 [4.65]	1 a
Colchicine		3 [3.2]		0 [0.0]		3 [4.0]	1 a		2 [4.17]		1 [2.33]	1 a
Infliximab		9 [9.5]		3 [15.0]		6 [8.0]	0.39 a		5 [10.42]		4 [9.3]	1 a
Other biologics		5 [5.3]		1 [5.0]		4 [5.3]	1 a		3 [6.25]		2 [4.65]	1 a
Cyclosporine		1 [1.1]		0 [0.0]		1 [1.3]	1 a		0 [0]		1 [2.33]	0.47 a
Methotrexate		3 [3.2]		1 [5.0]		2 [2.7]	0.51 a		1 [2.08]		2 [4.65]	0.6 a
Azathioprine		11 [11.6]		2 [10.0]		9 [12.0]	1 a		5 [10.42]		6 [13.95]	0.61 c
Antibiotics		7 [7.4]		1 [5.0]		6 [8.0]	1 a		7 [14.6]		0 [0.0]	0.013 a
Recurrence of SS, n [%]	95	22 [23.2]	20	4 [20.0]	75	18 [24.0]	N/A		12 [25]		9 [20.93]	0.65 c

Abbreviations: HEENT, head eyes ears nose throat; NSAID, non-steroidal anti-inflammatory drug; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; NDDH, neutrophilic dermatosis of the dorsal hands; AZA, azathioprine; N, number.

p-values in italic/bold are of values <0.05.

^aFisher’s exact test.

^bMann–Whitney U test.

^cPearson’s Chi-square test.