TABLE 1.

Mediators of iron metabolism in MIRI-associated diseases.

Molecule	Regulatory effects
HIF	Enhances TfR1 expression and exasperates iron overload and ROS production
FTH	Binds iron and suppresses cardiomyocyte capacity
MFRN	Regulates mitochondrial iron import
MCU	Regulates mitochondrial calcium uniporter
ABCB8	Augments mitochondrial iron output
IRP	Modulates iron intake, reservation, and release
IRE	Regulates the synthesis of iron metabolism–associated proteins
FPN	Mobilizes and releases ferrous ion to peripheral circulation
FtMt	Inputs iron and redistributes iron from the cytosol to mitochondria
DMT-1	Promotes iron indrawal and inputs iron

Abbreviations: HIF, hypoxia-inducible factor; FTH, ferritin heavy chain; MFRN, mitoferrin 2; MCU, mitochondrial calcium uniporter; ABCB8, ATP-binding cassette subfamily B member 8; IRP, iron regulatory proteins; IRE, iron-responsive elements; FPN, ferroportin; FtMt, mitochondrial ferritin; and DMT-1, divalent metal transporter 1.