TABLE 2.

Ferroptosis initiators and inhibitors: targeting strategy for MIRI.

Reagent	Effects	Targets	Key mechanisms	References
Erastin	Induction	System Xc-	GSH depletion and GPX4 inactivation	Yagoda et al. (2007); Yang et al. (2014)
RSL3	Induction	GPX4	Binds GPX4 protein and increases ROS generation	Huang et al. (2021)
BSO	Induction	System Xc-	Suppresses peripheral GSH biosynthesis	Harris et al. (2015)
Lanperisone	Induction	System Xc-	Promotes ROS production	Shaw et al. (2011)
Sorafenib	Induction	System Xc-	Interdicts GSH biosynthesis	Zhang et al. (2013); Louandre et al. (2015)
Sulfasalazine	Induction	System Xc-	Downregulates SLC7A11 expression	Sehm et al. (2016)
DPI 7,10, 12	Induction	GPX4	Binds GPX4 and augments ROS production.	Sharma and Flora, (2021)
Ferrostatin-1	Inhibition	ROS	Prevents ROS generation	Yin et al. (2011)
Liproxstatin-1	Inhibition	ROS	Prevents lipid peroxidation	Zhang et al. (2019b)
Zileuton	Inhibition	5-Lipoxygenase	Inhibits PUFAs catalyzing into hyperoxide	Kagan et al. (2017)
Vitamin E	Inhibition	5-Lipoxygenase	Inhibits PUFAs catalyzing into hyperoxide	Liu et al. (2015)
Deferoxamine	Inhibition	Fe2+	Chelates intracellular superfluous iron	Doll and Conrad, (2017)
XJB-5-131	Inhibition	ROS	Eliminates poisonous ROS	Doll and Conrad, (2017)
Mitoquinone	Inhibition	ROS	Eliminates mitochondrial ROS	Fuchs and Steller, (2011)